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Title:	Secondary chromosomal changes in 34 Philadelphia-chromosome– positive chronic myelocytic leukemia patients from the Mexican West. Short communication
Publisher:	Elsevier Inc.
Description:	The clonal evolution in t(9;22)-positive chronic myelocytic leukemia (CML) is well established. Four major changes occur in more than 70% of patients: +8, i(17q), +19, and an extra Philadelphia chromosome. The frequencies of secondary chromosomal changes in 34 patients from the states of Jalisco, Nayarit, Michoacán, and Colima (the Mexican West) with Philadelphia-chromosome–positive CML were assessed. The most frequent abnormalities were tetraploidy (12 cases); +8, inv(3)(q21q26), and octoploidy (3 cases each); and +der(22)(2 cases). Some translocations not previously associated with CML were observed, such as t(2;7)(p12;q36), t(3;6)(q26;p25), t(3;17)(q26;p13), and t(6;17)(q21;q23∼q25). Significant differences were found for +8 with respect to population results from Japan and from southern, eastern, and western Europe; for i(17)(q10) from eastern Europe; for +19 from Japan and western Europe; and for +der(22) from Japan, southern Europe, and western Europe. Although polyploidy could result from endomitosis, there is no direct evidence that the BCR/ABL protein influences such a process; however, protein kinases such as MAPK, which are involved in endomitosis, are activated by the BCR/ABL protein, and so the BCR/ABL protein could promote endomitosis through the MAPK pathway. Doctorado en Genética Humana, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico Laboratorio de Citogenética, División de Genética, Centro de Investigación Biomédica de Occidente, Centro Médico Nacional de Occidente,Instituto Mexicano del Seguro Social (CIBO-IMSS), Guadalajara, Jalisco, Mexico
URI:	https://hdl.handle.net/20.500.12104/72571
Other Identifiers:	0165-4608 DOI:10.1016/S0165-4608(03)00283-8 http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/374
Appears in Collections:	CUALTOS

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