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|Title:||Isodicentric Y chromosomes and secondary microchromosomes.|
|Keywords:||isodicentric;Y-chromosomes;microchromosomes;functional dicentricity;centromere excision|
|Description:||We report here on two mosaic patients with both an idic(Yp) and a microchromosome. FISH with the DYZ3 alphoid repeat demonstrated that the isodicentrics effectively exhibited two alphoid clusters whereas the small markers had a Y-centromere. These data, along with 4 previous observations, indicate that such microchromosomes effectively result from functional dicentricity of isodicentric Y-chromosomes and represent the excision of one centromere plus various amounts of adjacent chromatin. Other than a real infrequency of such a concurrence or a very low proportion of the cell line(s) containing the microchromosome, the paucity of observations points to a high rate of underdiagnosis as revealed by two idic(Y) instances in which the microchromosome was detected only in samples assessed by FISH.|
Instituto Mexicano del Seguro Social, División Genética, Guadalajara, Jalisco, Mexico
|Appears in Collections:||CUALTOS|
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