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Title: Increased expression of AML1-a and acquired chromosomal abnormalities in childhood acute lymphoblastic leukemia
Review article
Keywords: AML1-a isoform;gene expression;acquired chromosomal abnormalities
Publisher: Wiley Online Library
Description: A semi-quantitative expression analysis of both AML1-a and AML1-total was performed by RT-PCR in 19 children with acute lymphoblastic leukemia (ALL) at diagnosis. AML1-a expression was assessed in 16 bone marrow (BM) and 13 peripheral blood (PB) samples whereas AML1-total was assessed in 17 BM and 16 PB samples. These analyses were also carried out in 15 PB samples of healthy controls. In addition, 18/19 patients were karyotyped: 11 had an unmodified constitutional karyotype (CK) and seven exhibited acquired chromosomal abnormalities (ACA). The expression of AML1-a was significantly increased in BM and PB when compared with the controls (p < 0.013 and p < 0.035, respectively). A significant increase was found in the expression of AML1-a in BM of the ACA group compared with the CK group (p < 0.0009). The expression of AML1-a in BM and PB showed a significant increase in the ACA group compared with controls (p < 0.00001 and p < 0.012, respectively); in contrast, the CK group did not differ from the controls. These observations may mean that the increase of AML1-a favours the progression of leukemia.
División de Genética, Centro de Investigación Biomédica de Occidente, IMSS, Tepatitlán, Jalisco, México Departamento de Hematología, Hospital de Pediatría, IMSS, Tepatitlán, Jalisco, México Universidad de Guadalajara, Centro Universitario de los Altos, Tepatitla´n, Jalisco, México. CONACYT; contract/grant numbers: 39024-M; 117466; 12445 and 124931.
Other Identifiers: Gutiérrez-Angulo, M., González-García, J. R., Meza-Espinoza, J. P., Picos-Cárdenas, V. J., Esparza-Flores, M. a., López-Guido, B., & Rivera, H. (2004). Increased expression of AML1-a and acquired chromosomal abnormalities in childhood acute lymphoblastic leukemia. Hematological Oncology, 22(3), 85–90.
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