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Título:	Prolactin and Prolactin Receptor Expression In Cervical Intraepithelial Neoplasia and Cancer
Palabras clave:	cervical cancer;expression;prolactin;prolactin receptor
Editorial:	Pathology & Oncology Research
Descripción:	Prolactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P < 0.0003). The presence of the long isoform of the PRLR was observed only in cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer.
URI:	https://hdl.handle.net/20.500.12104/72414
Otros identificadores:	Ascencio-Cedillo, R., López-Pulido, E. I., Muñoz-Valle, J. F., Villegas-Sepúlveda, N., Del Toro-Arreola, S., Estrada-Chávez, C., Pereira-Suárez, A. L. (2014). Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer. Pathology Oncology Research. doi:10.1007/s12253-014-9814-6 1532-2807 http://148.202.112.41:8080/jspui/handle/123456789/174
Aparece en las colecciones:	CUALTOS

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